Preface.

PART I: ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.

1. Introduction.

2. Access to Sequence Data and Literature Information.

3. Pairwise Sequence Alignment.

4. Basic Local Alignment Search Tool (BLAST).

5. Advanced BLAST Searching.

PART II: GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.

6. Bioinformatic Approaches to Gene Expression.

7. Gene Expression: Microarray Data Analysis.

8. Protein Analysis and Proteomics.

9. Protein Structure.

10. Multiple Sequence Alignment.

11. Molecular Phylogeny and Evolution.

PART III: GENOME ANALYSIS.

12. Completed Genomes and the Tree of Life.

13. Completed Genomes: Viruses.

14. Completed Genomes: Bacteria and Archaea.

15. Eukaryotic Genomes: Fungi.

16. Eukaryotic Genomes: From Parasites to Primates.

17. Human Genome.

18. Human Disease.

Epilogue.

Appendix: GCG for Protein and DNA Analysis.

Glossary.

Solutions to Self-Test Quizzes.

Subject Index.

Author Index.