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What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd Edition
Jacqueline N. Crawley, PhD,
National Institute of Mental Health (NIMH), Porter Neuroscience Research Center, Bethesda, USA
ISBN: 978-0-471-47192-9
©2007
544 pages
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Description
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This new edition continues to provide the most thorough overview of mutant mouse technology and readable introduction to the field of behavioral neuroscience as applied to behavioral phenotyping of transgenic and knockout mice. Written in the same engaging, lively manner that is a trademark of the first edition, it has been fully updated to reflect the latest advances, from widespread use of conditional promoters and inducible systems to the applications of microarrays and proteomics. It also addresses the rapid developments in gene delivery technology, rescue techniques, stem cell transplantation, and knockdown and knock-in approaches. It also discusses the many exciting new targeted gene mutation models of human diseases that have been adopted by pharmaceutical companies for molecular screening and drug discovery research.
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